Comparison of Elderly Men with Low and Elevated Chronic Systemic Inflammation in Indices of Strength, Oxidative Stress and Inflammation

Authors

  • Dimitrios Draganidis University of Thessaly, Department of Physical Education and Sport Science
  • Athanasios Poulios University of Thessaly, Department of Physical Education and Sport Science
  • Vasiliki C. Laschou University of Thessaly, Department of Physical Education and Sport Science
  • Theofanis Tzatzakis University of Thessaly, Department of Physical Education and Sport Science
  • Konstantinos Papanikolaou University of Thessaly, Department of Physical Education and Sport Science
  • Savvas Kritikos University of Thessaly, Department of Physical Education and Sport Science
  • Chariklia K. Deli University of Thessaly, Department of Physical Education and Sport Science
  • Kalliopi Georgakouli University of Thessaly, Department of Physical Education and Sport Science
  • Alexandra Avloniti Democritus University of Thrace, Department of Physical Education and Sport Science
  • Aggelos Pappas University of Thessaly, Department of Physical Education and Sport Science
  • Athanasios Z. Jamurtas University of Thessaly, Department of Physical Education and Sport Science
  • Ioannis G. Fatouros University of Thessaly, Department of Physical Education and Sport Science

DOI:

https://doi.org/10.26253/heal.uth.ojs.ispe.2018.1514

Keywords:

chronic systemic inflammation, white blood cells, protein carbonyl, muscle strength

Abstract

The aim of the study was to examine differences among elderly men with low and elevated chronic systemic inflammation (CSI) in indices of the immune system, oxidative stress, antioxidant capacity and strength of the upper and lower body. A total of thirty-three, healthy, elderly men aged 65-75 years were included in the study and grouped as either ″low‶ CSI (LCSI: n=16; hs-CRP: < 1 mg/L) or ″elevated‶ CSI (ECSI: n=17; hs-CRP: > 1 mg/L) according to their serum levels of high-sensitivity CRP (hs-CRP). All participants were assessed for anthropometrics, body composition via Dual Emission X-ray Absorptiometry (DXA), handgrip strength and lower limb muscle strength on a leg extension machine. Blood samples were also collected for the determination of white blood cells (WBC), granulocytes (GRA), monocytes (MON) and lymphocytes (LYM) concentration as well as for the measurement of protein carbonyls (PC) and total antioxidant capacity (TAC) in serum. ECSI was characterized by almost a 4-fold greater hs-CRP value compared to LCSI (ECSI: hs-CRP = 0.6±0.1 mg/L vs LCSI: hs-CRP = 2.3±0.8 mg/L, p=0.00). ECSI and LCSI were comparable in terms of anthropometric characteristics, body mass index, fat percent, fat mass, fat free mass, lean body mass as well as in handgrip and lower limb muscle strength. Moreover, no differences were observed among groups in WBC, GRA, MON and LYM counts and in PC concentration. In contrast, significant differences observed between groups in TAC, with LCSI displaying a greater antioxidant capacity than ECSI by 60% (p<0.05). In conclusion, white blood cell counts and protein carbonyl concentration as well as muscle strength of the lower and upper body are not different among elderly men with ″low‶ CSI and ″elevated‶ CSI. However, those with low levels of CSI are characterized by a greater antioxidant capacity compared to their counterparts with elevated CSI.

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Published

2018-07-31

How to Cite

Draganidis Δ., Poulios Α., Laschou Β. Κ., Tzatzakis Θ., Papanikolaou Κ., Kritikos Σ., Deli Χ., Georgakouli Κ., Avloniti Α., Pappas Ά., Jamurtas Α. Ζ., & Fatouros Ι. Γ. (2018). Comparison of Elderly Men with Low and Elevated Chronic Systemic Inflammation in Indices of Strength, Oxidative Stress and Inflammation. Inquiries in Physical Education and Sport, 16(2), 96–105. https://doi.org/10.26253/heal.uth.ojs.ispe.2018.1514

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