Muscle Fatigue at the Motor Protein Level
Keywords:Muscle fatigue, sarcomeric proteins, skinned fibers, cross-bridge cycle, contractile properties
Muscle fatigue is a well known phenomenon observed not only in athletes but also in the daily lives of healthy individuals and patients with chronic diseases. Nevertheless, the mechanisms underlying muscle fatigue are complicated and include many stages from the central nervous system to the interaction of motor proteins, myosin and actin. In the current literature review the biochemical factors directly affecting the interaction of myosin with actin are presented and connected with the manifestations of muscle fatigue at the functional level. This information is also connected with sports performance of healthy individuals and the
changes in functional capacity of chronic patients.